9/24/2023 0 Comments Coronavirus spike proteinHere we summarize our current knowledge on the structure of the SARS-CoV-2 S protein and discuss the implications for vaccines and therapeutics. Remarkable progress in the structural biology of SARS-CoV-2 S protein has been made since the initial outbreak of the virus, substantially advancing our molecular understanding of the viral entry process. The protein is therefore an important target for development of diagnostics, therapeutics and vaccines. This first critical step of viral infection is catalyzed by its trimeric spike (S) protein, which decorates the virion surface as a major antigen and induces neutralizing antibody responses. Coronaviruses (CoVs) are enveloped positive-stranded RNA viruses that enter a host cell by fusion of its envelope lipid bilayer with the target cell membrane. A deep understanding of the structure-function relationships of viral proteins and relevant host factors will be required in order to meet these needs. There are urgent needs for innovative vaccine and therapeutic strategies to control this unprecedented crisis, as well as potential future needs if it becomes seasonal with continuous emergence of new variants. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 (coronavirus disease 2019) pandemic, and its infection has led to millions of lives lost and devastating socio-economic consequences throughout the globe. Learn more about the process for FDA approval. These vaccines were found to meet the high standards for safety, effectiveness, and manufacturing quality FDA requires of an approved product.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |